Pisgah, who went into Friday night's game with a 17-0 record, jumped out ahead early, beating FHS 74-54.
The Lady Panthers went on to play conference rivals Smoky Mountain High Tuesday night, but were unable to top the Mustangs, falling 48-42.
The Lady Mustangs handed the Panthers their 8th loss of the season, bringing them to a 9-8 season record and 5-4 in WNC conference play.
The boys varsity team battled Pisgah close, trailing just 10 points at the half.
In an equally impressive second half, the Panthers just weren't able to hang out, losing 61-51.